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Indications and recommendations for the use of HSC for the treatment of IBD released in 1995 by an international committee on four important criteria: (1) indestructibility to immunosuppressive treatment.; (2) the persistence of ailments identified with endoscopy, colonoscopy, or magnetic resonance enterography; (3) patients who have undergone an upcoming surgical intervention with a impeccable risk of developing short bowel syndrome or refractory colon disease; and 4) patients who refused treatment of persistent perianal lesions with coloproctectomy with definitive stroma implantation..28 in compliance with standard procedure, proprietary HSCs have been produced using cyclophosphamide, which is combined with granulocyte colony stimulating factor (g-csf), https://www.biofeedback-rhb.cz/edice-medicline/ in two different concentrations (4 g/m2 and 2 g/m2).